Tupelo

Best American Restaurants in Tupelo

Looking for the best American restaurants in Tupelo? We've gathered 18 spots serving American food in Tupelo, ranked by real diner reviews and ratings. Browse photos, check menus, and request a free reservation — all in one place. Updated June 2026.

Unclaimed

Best American Restaurants in Tupelo

Dairy Kream

Danver's

Kermit’s Outlaw Kitchen (KOK)

Cheers At Crosstown

Son-in-Law's

DAVEY DOGS

Back Yard Burgers

Sims Soul Cooking Restaurant

O'Charley's

Malibu Wings

IHOP

Newk's Eatery

Ryan's

Applebee's

Applebee's

Abner's Famous Chicken Tenders

Krumbs Homestyle Cooking

Texas Roadhouse