Picayune

Best American Restaurants in Picayune

Looking for the best American restaurants in Picayune? We've gathered 5 spots serving American food in Picayune, ranked by real diner reviews and ratings. Browse photos, check menus, and request a free reservation — all in one place. Updated June 2026.

Unclaimed

Best American Restaurants in Picayune

Chick N Stick Soulfood

The Depot on Canal

Applebee's

Chick n stick soul food

Applebee's

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